If your website won't load after updating to BuddyPress 12.1.1 it is likely a conflict with bbPress or another BuddyPress compatible plugin. Install the BP Classic plugin to fix this issue.

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I can't login after clicking my BuddyPress email activation link?

The issue is the page URL contains the activation link which does not work with the popup modal login window. To fix this use the BP Autologin on Activation plugin which automatically logs the user in after clicking the email activation link.